I believe that educators benefit from having a
deeper understanding of the conditions they teach about and work to
prevent. That includes pathophysiology
of diabetes. I love anatomy and physiology so I thought the image below was
interesting and helpful.
Diabetes is a very complex condition which affects
every single part of the body. There is much we don’t understand about diabetes
but we do know a lot. In type 2 diabetes, either
the body does not produce enough insulin or the cells are not using insulin properly (insulin
resistance). Insulin helps
the body use glucose for energy/fuel by taking the sugar from the blood and
delivering in into the cells. When there is insulin resistance or deficiency,
too much glucose builds up in the blood stream instead of entering the cells.
This is called hyperglycemia or high blood sugar, which lead to complications such
as blindness, kidney disease, amputations, nervous system disease, and oral
complications like gum disease and tooth loss (NDEP, 2007). Cardiovascular
disease is the major cause of death in people with diabetes (NDEP, 2007).
The diagram below shows how insulin resistance and
hyperglycemia (high blood sugar) lead to cardiovascular disease. Insulin
resistance leads to decreased glucose uptake by the muscles, an increased
breakdown of fat to supply the body’s energy needs which then also leads to an
even further increase of glucose production resulting in hyperglycemia, too
much sugar in the blood (Pitta, 2004). Insulin resistance & hyperglycemia increase
risk for CVD by increasing blood pressure, affecting blood lipid levels
(cholesterol & triglycerides) and increasing clotting.
There are many factors that affect an individual’s
risk for developing diabetes but the major factors are weight, activity level,
eating habits and genetics. Three out of
these four are modifiable and closely inter-related.
Obesity is a major problem in the U.S. and is largely affected by our poor dietary habits and sedentary lifestyles. There
is a clear association between obesity and insulin resistance. Increased fat
makes it harder for the body to use insulin, it increases insulin resistance.
Most people are overweight when they are diagnosed with diabetes (NDEP, 2007).
Figures 1
& 2 below show an increase in diabetes prevalence from 1990 – 2000s parallel
to the increase in obesity prevalence.
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| Source: NDEP, 2007 |
The two
are so closely related they are often referred to as diabesity. We have to
address both obesity and diabetes to truly have an impact on our country’s
health status.
References
U.S. Centers for Disease Control and Prevention. (2012). Diabetes data and trends. Retrieved from http://www.cdc.gov/diabetes/statistics/
National Diabetes Education Program. (2007). Working together to manage diabetes: a guide for pharmacists, podiatrists, optometrists, and dental professionals, 2007. Retrieved from
National Diabetes Education Program. (2007). Working together to manage diabetes: a guide for pharmacists, podiatrists, optometrists, and dental professionals, 2007. Retrieved from
http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=26#page6
Pitta, A.
G. (2004). Diabetes Mellitus: Diagnosis and Pathophysiology. Retrieved from
Tufts University Open Courseware website:
http://ocw.tufts.edu/Content/14/lecturenotes/265878



